How do I delete a file windows won't let me.

[TMP]

I have a file on my desktop I really don't want, but if I try to delete it I get thats it's in use by another program or a person, and I can't find the program that would be using it!

There must be a way do to this is command prompt, what would the command be?
(I completely forgot how to use it).

[Muderman24]

boot in safe mode and delete it

[Websk8ter]

msconfig and disable every thing then rebot and delete it then just reactivate everything and reboot again.

that might work

[A|fzZz]

check processes in task manager...u might fiind sth....